Adiponectin and nitric oxide production in normotensive and hypertensive men

作者：Tsuda Kazushi^*

来源：CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2007, 34(s1): S64-S66.

DOI：10.1111/j.1440-1681.2007.04782.x

• adiponectin
• hypertension
• men
• nitric oxide

1. In the present study, we examined the possible relationship between circulating adiponectin and plasma levels of nitric oxide (NO) metabolites (nitrite and nitrate) in normotensive and hypertensive men.
2. The concentration of circulating adiponectin was significantly lower in hypertensive men compared with normotensive men. Plasma levels of NO metabolites were also reduced in hypertensive men compared with normotensive men.
3. Circulating adiponectin was significantly correlated with plasma levels of NO metabolites (nitrite and nitrate) in the overall analysis of normotensive and hypertensive men (r = 0.377; n = 52; P < 0.01). When analysis of the correlation for normotensive and hypertensive men was performed separately, there was a significant correlation between circulating adiponectin and plasma levels of NO metabolites in normotensive men, but not in hypertensive men.
4. The results of the present study are consistent with the hypothesis that adiponectin-mediated production of NO may be altered in hypertensive men.

• 出版日期2007-11