MULTI-DRUG RESISTANT TB AND HIV IN THAILAND: OVERLAPPING, BUT NOT INDEPENDENTLY ASSOCIATED RISK FACTORS

作者：Akksilp Somsak; Wattanaamornkiat Wanpen; Kittikraisak Wanitchaya; Nateniyom Sriprapa; Rienthong Somsak; Sirinak Chawin; Ngamlert Keerataya; Mankatittham Wiroj; Sattayawuthipong Wanchai; Sumnapun Surin; Yamada Norio; Monkongdee Patama; Anuwatnonthakate Amornrat; Burapat Channawong; Wells Charles D; Tappero Jordan W; Varma Jay K^*

来源：Southeast Asian Journal of Tropical Medicine and Public Health, 2009, 40(6): 1264-1278.

The HIV and multi-drug resistant tuberculosis (MDR-TB) epidemics are closely linked. In Thailand as part of a sentinel surveillance system, we collected data prospectively about pulmonary TB cases treated in public clinics. A subset of HIV-infected TB patients identified through this system had additional data collected for a research study. We conducted multivariate analysis to identify factors associated with MDR-TB. Of 10,428 TB patients, 2,376 (23%) were HIV-infected; 145 had MDR-TB. Of the MDR-TB cases, 52 (37%) were HIV-infected. Independent risk factors for MDR-TB included age 18-29 years old, male sex, and previous TB treatment, but not HIV infection. Among now patients, having an injection drug use history was a risk factor for MDR-TB. Of 539 HIV-infected TB patients in the research Study, MDR-TB was diagnosed. in 19 (4%); the only significant risk factors were previous TB treatment and previous hepatitis. In Thailand, HIV is common among MDR-TB patients, but is not an independent risk factor for MDR-TB Populations at high risk for HIV-young adults, men, injection drug users - should be prioritized for drug susceptibility testing.

• 出版日期2009-11