Leukemic Transdifferentiation of Follicular Lymphoma Into an Acute Histiocytic Leukemia in a 52-Year-Old Caucasian Woman

作者：Steussy Bryan; Lekostaj Jacqueline; Qian Qining; Rosenthal Nancy; Holman Carol J; Syrbu Sergei; Darbro Benjamin; Bossler Aaron; Karandikar Nitin J^*

来源：Laboratory Medicine, 2016, 47(2): 155-157.

DOI：10.1093/labmed/lmw011

• transdifferentiation
• lymphoma
• leukemia
• histiocytic
• sarcoma
• B cell

We report an instructive case of acute myeloid leukemia with histiocytic differentiation (acute histiocytic leukemia) arising in a patient, a 52-year-old woman with a history of follicular lymphoma. The results of genetic studies proved a clonal relationship between the lymphoma and the leukemic cells. To our knowledge, this is the first report of leukemic transdifferentiation of follicular lymphoma into modified base 5-methylcytosine (M(5)c)-like acute histiocytic leukemia and the first reported karyotype on a transdifferentiated neoplasm.

• 出版日期2016-5