Asymmetric epoxidation of alkenes and benzylic hydroxylation with P450tol monooxygenase from Rhodococcus coprophilus TC-2

作者：Li Aitao; Wu Shuke; Adams Joseph P; Snajdrova Radka; Li Zhi^*

来源：Chemical communications, 2014, 50(63): 8771-8774.

DOI：10.1039/c4cc03491k

P450tol monooxygenase was discovered as a unique and highly enantioselective enzyme for asymmetric epoxidation of some terminal alkenes containing electron-withdrawing groups and benzylic hydroxylation of several ethylbenzenes giving the corresponding useful and valuable products, such as (R)-2- and 3-substituted styrene oxides, (S)-4-substituted styrene oxides, and (S)-benzylic alcohols, in high ee.

• 出版日期2014-8-14