A Modular 'Click' Approach to Substituted 2,2 '-Bipyridines

作者：Fabbrizzi Pierangelo; Cecconi Bianca; Cicchi Stefano^*

来源：Synlett, 2011, (2): 223-226.

DOI：10.1055/s-0030-1259304

• cycloaddition
• azides
• alkynes
• copper
• ligands

The CuAAC reaction was used for the development of a click approach to a series of triazole-substituted bipyridinyl derivatives. 4,4'-Diethinyl 2,2'-bipyridine and 4,4'-diazido 2,2'-bipyridine were synthesized and tested in the cycloaddition reactions. While 4,4'-diazido 2,2'-bipyridine revealed unreactive in CuAAC reactions, its corresponding N,N'-dioxide afforded the expected cycloaddition product.

• 出版日期2011-1-11