Modified Tapvei OU Stairs Induce an Anxiolytic Effect in Female C57BL/6 Mice in the Elevated Plus-Maze Test

作者：Oekva K^*; Nevalainen E; Mauranen K; Pokk P

来源：Scandinavian Journal of Laboratory Animal Science, 2012, 39(1): 5-9.

We evaluated the effect of modified Tapvei OU stairs (stairs) on the behaviour of female C57BL/6 and BALB/c mice in the elevated plus-maze (EPM) test. The mice were kept under standard conditions for weeks%26apos; (control) or exposed to stairs for 3 or 4 weeks, and were assessed thereafter with the RPM. The C57BL/6 mice displayed less anxiety, when compared with the BALB/c mice. Exposure to stairs had an anxiolytic effect in C57BL/6 mice, but not in BALB/c. The strain-dependent effects of stairs should be considered in the design of housing refinements and behavioural experiments.

• 出版日期2012