科研之友
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摘要
The beta-amino carboxylic acid moiety is a key feature of numerous important biologically active compounds. We describe a syn-selective direct Mannich addition reaction that uses alpha-iodo thioesters and sulfonyl imines and produces beta-amino thioesters. Enolate formation is achieved by reductive soft enolization. The products of the reaction provide straightforward access to biologically important beta-lactams through a variety of known reactions.
- 出版日期2016
