AKT2 expression in histopathologic grading and recurrence of meningiomas

作者：Wang, Q.; Fan, S. -Y.; Qian, J.; Wang, J. -Y.; Lu, Y. -C.^*; Hu, G. -H.; Luo, C.

来源：European Journal of Surgical Oncology, 2014, 40(9): 1056-1061.

DOI：10.1016/j.ejso.2014.02.243

• AKT2
• Meningioma
• Ki-67
• Tumor grade
• Recurrence

Background: AKT2 (protein kinase B), an important protein in PI3K signaling pathway, is overexpressed in a variety of malignant tumors. However, in patients With meningiomas, the potential correlation between AKT2 and clinical outcome remains unknown.
Methods: The expression of AKT2 and Ki-67 in meningioma tissues were evaluated immunohistochemically in 94 patients with meningiomas. The correlation of AKT2 immunoreactivity with clinicopathological features and the prognostic value of AKT2 in patients were also analyzed.
Results: In this study, we examined the expression of AKT2 in meningiomas and unveiled its possible relationship with the clinical outcome. Immunohistochemical analysis revealed high AKT2 expression in 46 patients (46/94, 48.9%) and low AKT2 expression in the remaining 48 patients (48/94, 51.1%). There was a positive correlation between AKT2 and Ki-67 immunoreactivity (r = 0.35, P = 0.01). Clinicopathological evaluation suggested that AKT2 expression was associated with pathological grade and recurrence (P < 0.05). Univariate and Cox analysis indicated a significant correlation between high levels of AKT2 immunoreactivity and high rates of tumor recurrence (P < 0.05).
Conclusions: We conclude that AKT2 may play an important role in the development of meningioma. High AKT2 labeling index indicates. higher grade of meningioma, and therefore AKT2 may be a useful molecular marker for predicting the prognosis of meningioma.

• 出版日期2014-9
• 单位天津市中医药研究院附属医院; 中国人民解放军第二军医大学