Mitochondrial dynamics in the regulation of neurogenesis: From development to the adult brain

作者：Khacho Mireille; Slack Ruth S^*

来源：Developmental Dynamics, 2018, 247(1): 47-53.

DOI：10.1002/dvdy.24538

• mitochondria
• mitochondrial dynamics
• metabolism
• neural stem cells
• neurogenesis
• stem cell self-renewal
• cell fate decisions

Mitochondria are classically known to be the cellular energy producers, but a renewed appreciation for these organelles has developed with the accumulating discoveries of additional functions. The importance of mitochondria within the brain has been long known, particularly given the high-energy demanding nature of neurons. The energy demands imposed by neurons require the well-orchestrated morphological adaptation and distribution of mitochondria. Recent studies now reveal the importance of mitochondrial dynamics not only in mature neurons but also during neural development, particularly during the process of neurogenesis and neural stem cell fate decisions. In this review, we will highlight the recent findings that illustrate the importance of mitochondrial dynamics in neurodevelopment and neural stem cell function. Developmental Dynamics 247:47-53, 2018.

• 出版日期2018-1