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摘要
Three new isoprenylated 2-arylbenzofurans, namely artostyracins A-C (1-3, resp.), together with a known one (4), were isolated from the root of Artocarpus styracifolius Pierre. Their structures were determined by spectroscopic methods (1D and 2D NMR, UV, IR, and HR-ESI-MS). All of the compounds were evaluated for the anti-respiratory burst properties using a cellular model reproduced by chemical stimulation of rat neutrophils. Compounds 1 and 3 offered the potently inhibitory effects on respiratory burst of rat neutrophils with IC50 values of 1.42 and 1.91 mu M, while compounds 2 and 4 revealed moderate suppression activity with IC50 values of 11.56 and 46.91 mu M.
- 出版日期2014-12
- 单位江西中医药大学
