Association between serum uric acid and the characteristics of coronary plaque burden: assessment with coronary CT angiography

作者：Tan, Ruiyi; Jiang, Chunyan; Xiang, Hang; Hong, Nan^*

来源：International Journal of Clinical and Experimental Medicine, 2017, 10(8): 12250-+.

• Uric acid
• coronary plaque burden
• coronary CT angiography
• gender

Objective: It is controversial whether serum uric acid (UA) is an independent risk factor for cardiovascular diseases (CVD). The aim of this study was to investigate the correlation between the serum UA level and coronary plaque burden characteristics evaluated by coronary CT angiography (CCTA). Methods: In total, 1315 patients who underwent CCTA were divided into the hyperuricemia group and normal serum UA group according to their serum UA level and stratified by gender. The low-attenuation plaque volume (LPV) and total plaque volume (TPV) were separately measured in each main coronary artery. The correlation of serum UA or hyperuricemia with coronary plaque burden was assessed using multivariate-adjusted linear regression analyses. Results: The TPV and LPV significantly differed between males and females (P < 0.0001 each). The TPV values in female with hyperuricemia group were higher than in subjects without hyperuricemia (P = 0.0124). The serum UA level significantly correlated with the TPV in both genders (beta = 0.4231 and P = 0.0441 for males and beta = 0.4996 and P = 0.0149 for females). However, the serum UA and LPV did not correlate with either gender after adjusting for multivariates. Conclusion: The serum UA level was significantly associated with the coronary TPV in both genders. However, the serum UA was not associated with the LPV. We found that the serum UA may play an independent role in the pathophysiology of total plaque burden.

• 出版日期2017
• 单位中国人民解放军总医院; 北京大学