Direct C-H bond arylation of 2-hydroxybenzaldehydes with arylboronic acids via ligand-free palladium catalysis

作者：Weng, Fei; Wang, Chengming; Xu, Bin^*

来源：Tetrahedron Letters, 2010, 51(19): 2593-2596.

DOI：10.1016/j.tetlet.2010.02.166

• Arylboronic acids
• C-H Bond arylation
• 2-Hydroxybenzaldehydes
• 2-Hydroxybenzophenones
• Palladium-catalyzed

A mild and efficient ligand-free palladium-catalyzed direct C-H bond arylation reaction was developed to afford 2-hydroxybenzophenones in good to excellent yields from easily available 2-hydroxybenzaldehydes and arylboronic acids. The given reaction provided one of the easiest pathways for accessing 2-hydroxybenzophenones, and a variety of functional groups could be tolerated in this process.

• 出版日期2010-5-12
• 单位上海大学