Dual effects of HTLV-1 bZIP factor in suppression of interferon regulatory factor 1

作者：Mukai Risa; Ohshima Takayuki^*

来源：Biochemical and Biophysical Research Communications, 2011, 409(2): 328-332.

DOI：10.1016/j.bbrc.2011.05.014

• HTLV-1
• HBZ
• IRF-1
• Transcriptional regulation

Human T-cell leukemia virus type-1 (HTLV-1) causes ATL in 2.5% of carriers after a long period of latent infection. Moreover, half of adult T-cell leukemia (ATL) patients succumb to this disease within 1 year of onset. HTLV-1 bZIP factor (HBZ) is constitutively expressed in all the ATL cells. Thus, suggesting that HBZ may play a key role in cellular leukemogenesis. Herein we present evidence that interferon regulatory factor IRF-1, which is a member of IRF transcription family, interacts with HBZ. The N-terminal of HBZ interacted with IRF-1. HBZ reduced both IRF-1 DNA-binding activity and stability via a proteasome-dependent pathway. In addition, IRF-1-mediated apoptosis is significantly reduced by ectopic production of the HBZ. These results suggested that HBZ has dual suppressive effects on IRF-1 function, which may contribute to HTLV-1 related pathogenesis.

• 出版日期2011-6-3