Amyloid Burden, Neuronal Function, and Cognitive Decline in Middle-Aged Adults at Risk for Alzheimer's Disease

作者：Okonkwo Ozioma C^*; Oh Jennifer M; Koscik Rebecca; Jonaitis Erin; Cleary Caitlin A; Dowling N Maritza; Bendlin Barbara B; LaRue Asenath; Hermann Bruce P; Barnhart Todd E; Murali Dhanabalan; Rowley Howard A; Carlsson Cynthia M; Gallagher Catherine L; Asthana Sanjay; Sager Mark A; Christian Brad T; Johnson Sterling C

来源：Journal of the International Neuropsychological Society, 2014, 20(4): 422-433.

DOI：10.1017/S1355617714000113

• fMRI
• Preclinical AD
• Family history of AD
• FDG
• Amyloid
• Longitudinal cognitive decline

The relative influence of amyloid burden, neuronal structure and function, and prior cognitive performance on prospective memory decline among asymptomatic late middle-aged individuals at risk for Alzheimer's disease (AD) is currently unknown. We investigated this using longitudinal cognitive data from 122 middle-aged adults (21 "Decliners" and 101 "Stables") enrolled in the Wisconsin Registry for Alzheimer's Prevention who underwent multimodality neuroimaging [C-11-Pittsburgh Compound B (PiB), F-18-fluorodeoxyglucose (FDG), and structural/functional magnetic resonance imaging (fMRI)] 5.7 +/- 1.4 years (range = 2.9-8.9) after their baseline cognitive assessment. Covariate-adjusted regression analyses revealed that the only imaging measure that significantly distinguished Decliners from Stables (p = .027) was a Neuronal Function composite derived from FDG and fMRI. In contrast, several cognitive measures, especially those that tap episodic memory, significantly distinguished the groups (p's<.05). Complementary receiver operating characteristic curve analyses identified the Brief Visuospatial Memory Test-Revised (BVMT-R) Total (.82 +/- .05, p < .001), the BVMT-R Delayed Recall (.73 +/- .06, p = .001), and the Reading subtest from the Wide-Range Achievement Test-III (.72 +/- .06, p = .002) as the top three measures that best discriminated the groups. These findings suggest that early memory test performance might serve a more clinically pivotal role in forecasting future cognitive course than is currently presumed. (JINS, 2014, 20, 1-12)

• 出版日期2014-4