Will dapivirine redeem the promises of anti-HIV microbicides? Overview of product design and clinical testing

作者：das Neves Jose; Martins Joao Pedro; Sarmento Bruno

来源：Advanced Drug Delivery Reviews, 2016, 103: 20-32.

DOI：10.1016/j.addr.2015.12.015

• ASPIRE
• Pre-exposure prophylaxis
• The Ring Study
• Vaginal film
• Vaginal gel
• Vaginal ring

Microbicides are being developed in order to prevent sexual transmission of HIV. Dapivirine, a non-nucleoside reverse transcriptase inhibitor, is one of the leading drug candidates in the field, currently being tested in various dosage forms, namely vaginal rings, gels, and films. In particular, a ring allowing sustained drug release for 1 month is in an advanced stage of clinical testing. Two parallel phase III clinical trials are underway in sub-Saharan Africa and results are expected to be released in early 2016. This article overviews the development of dapivirine and its multiple products as potential microbicides, with particular emphasis being placed on clinical evaluation. Also, critical aspects regarding regulatory approval, manufacturing, distribution, and access are discussed.

• 出版日期2016-8-1