A 15-day oral dose toxicity study of aspirin eugenol ester in Wistar rats

作者：Li, Jianyong^*; Yu, Yuanguang; Yang, Yajun; Liu, Xiwang; Zhang, Jiyu; Li, Bing; Zhou, Xuzheng; Niu, Jianrong; Wei, Xiaojuan; Liu, Zhiqi

来源：Food and Chemical Toxicology, 2012, 50(6): 1980-1985.

DOI：10.1016/j.fct.2012.03.080

• Aspirin eugenol ester (AEE)
• Subchronic toxicity
• Rats

The subchronic toxicity of aspirin eugenol ester (AEE) was evaluated after 15-day intragastrically administration in rats at daily doses of 50, 1000, and 2000 mg/kg. AEE at low-dose showed no toxicity to the tested rats. Following repeated exposure to medium- or high-dose of AEE, apparent changes were observed in the levels of blood glucose, AST, ALP. ALT and TB in both male and female rats, and appeared to be dose-independent. There were no significant gender differences in most indexes of subchronic toxicity throughout the experimental period with the exception of food consumption and body weight. The no-observed-adverse-effect level (NOAEL) of AEE was considered to be 50 mg/kg/day under the present study conditions.

• 出版日期2012-6
• 单位中国农业科学院; 兰州理工大学