ADAM33 genetic polymorphisms and risk of atopic dermatitis among Japanese children

作者：Matsusue Aya; Kiyohara Chikako^*; Tanaka Keiko; Sasaki Satoshi; Miyake Yoshihiro

来源：Clinical Biochemistry, 2009, 42(6): 477-483.

DOI：10.1016/j.clinbiochem.2008.12.014

• ADAM33
• Atopic dermatitis
• Genetic susceptibility
• Haplotype
• Japanese children
• SNP

Objectives: ADAM33, a disintegrin and metalloproteinase 33, gene has been identified as,in asthma Susceptibility gene. The relationship between single nucleotide polymorphisms (SNPs) in ADAM33 and atopic dermatitis (AD) in Japanese children was examined using case-control design.
Methods: Seven SNPs of ADAM33 (rs2853209, rs2787094, rs2280091, rs2280090, rs628977, rs597980, and rs528557) were analyzed in 140 At) cases and 258 controls aged 3 years.
Results: Only rs2853209 (T > A) was significantly associated with AD risk. Sex-adjusted odds ratio (OR) for the AA versus the TT genotype was 0.55 (95% confidence interval (CI), 0.30-0.997). Consistent with the results of genotyping analysis, a haplotype carrying rs2853209 A allele was significantly associated with decreased risk of AD compared to all the other haplotypes combined (OR=0.26, 95% CI=0.08-0.69).
Conclusion: This is the first study to provide evidence for an association of the ADAM33 polymorphism with AD risk but the strength of this evidence is limited by our small sample size.

• 出版日期2009-4