A novel polymer-free dual-drug eluting stent with nanotechonology

作者：俞梦越; 张海华; 徐波; 吴永健; 颜红兵; 陈珏; 钱杰; 乔树宾; 杨跃进; 高润霖

来源：South China Journal of Cardiology, 2013, 14(03): 204-210.

• nanotechnology
• drug eluting stents
• polymer-free
• human trial

Durable polymers used for first-generation drug-eluting stents potentially contribute to persistent inflammation and late stent thrombosis.BICARE(Lepu Medical Technology Co.,Ltd,Beijing,China) is a novel polymer-free stent system with nanotechnology and elutes rapamycin(1.6μg/mm2) and probucol(0.8μg/mm2).The millpores on the surface of the stents were produced by nanotechnology.Studies on in-vitro release profile and the preliminary feasibility and safety of the BICARE stent were conducted.The results of release profile study demonstrated the ability of dual-drug polymer-free loading stents to release rapamycin and probucol in a controlled and sustained manner.The preliminary feasibility and safety of BICARE dual-drug polymer-free stent are demonstrated firstly in human study.Optical coherence tomography(OCT) findings indicated excellent stent strut coverage at 4-month.Further pivotal randomized trial will confirm if this early results could translate into longer term safety and efficacy benefits.

• 出版日期2013
• 单位心血管疾病国家重点实验室; 中国医学科学院北京协和医院; 北京协和医学院