NSAID Single-Drug-Induced Reactions

作者：Woessner Katharine M^*; Castells Mariana

来源：Immunology and Allergy Clinics of North America, 2013, 33(2): 237-+.

DOI：10.1016/j.iac.2012.12.002

• Nonsteroidal anti-inflammatory drugs (NSAIDs)
• Adverse drug reactions (ADRs)
• Stevens-Johnson syndrome (SJS)
• Toxic epidermal necrolysis (TEN)
• Drug rash with eosinophilia and systemic symptoms (DRESS)
• Acute generalized erythematous pustulosis (AGEP)

Nonsteroidal anti-inflammatory drugs (NSAIDs) are cyclooxygenase inhibitors with analgesic, anti-inflammatory, antipyretic, and antithrombotic effects. NSAIDs have been implicated in a variety of drug-induced reactions that are proved as or suspected of being mediated through a host immune response. Single-drug-induced reactions are the hallmark of these types of reactions. The types of single-drug-induced reactions are the confluence of 2 variables, the structure of the drug and the specific types of immune responses. This article identifies reactions patterns and the NSAIDs most likely to elicit each immune response.

• 出版日期2013-5