Universal protein distributions in a model of cell growth and division

作者：Brenner, Naama^*; Newman, C M; Osmanovic, Dino; Rabin, Yitzhak; Salman, Hanna; Stein, D L

来源：Physical Review E, 2015, 92(4): 042713.

DOI：10.1103/PhysRevE.92.042713

• Distribution shapes
• High-accuracy
• Protein contents
• Protein distributions
• Single parameter
• Stochastic growth
• Temporal Data
• Temporal measurements

Protein distributions measured under a broad set of conditions in bacteria and yeast were shown to exhibit a common skewed shape, with variances depending quadratically on means. For bacteria these properties were reproduced by temporal measurements of protein content, showing accumulation and division across generations. Here we present a stochastic growth-and-division model with feedback which captures these observed properties. The limiting copy number distribution is calculated exactly, and a single parameter is found to determine the distribution shape and the variance-to-mean relation. Estimating this parameter from bacterial temporal data reproduces the measured distribution shape with high accuracy and leads to predictions for future experiments.

• 出版日期2015-10-23
• 单位华东师范大学