科研之友
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摘要
Alismanin A(1), a novel aromatic triterpenoid with a C-34 skeleton, was isolated from Alisma orientale together with a rearrange nor-triterpenoid (2) and a 13,17-seco triterpenoid (3). Their structures were determined by a combination of HRESIMS, 2D NMR spectra, electronic circular dichroism (ECD), theoretical calculations, and X-ray diffraction analysis. Compounds 1 and 2 displayed significant activation effects on pregnane X receptor. (PXR) at 10 nM. A plausible biosynthetic pathway for 1-3 is also discussed.
