科研之友
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摘要
In this study, we demonstrated a novel targeting drug carrier formed by amphiphilic prodrug based mixed micelle. Along with octadecyl chains, chemical bonded Dox moieties were utilized to entrap free drugs (PTX) and simultaneously acted as therapeutic agents. The formulation of CP-Folate/CPN = Dox/PTX showed spherical micellar structure and possessed high drug loading content, which was up to 22.9%. We examined the cell uptaken capacity and the cytotoxicity of mixed micelle by CLSM and MTT assay. The introducing of folate moiety enhanced intracellular accumulation in HeLa cells and co-delivery of Dox and PTX showed stronger anti-tumor activity even compared with free drugs.
