科研之友
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摘要
A new staurosporine analog, 10'-{5 ''-[(methoxycarbonyl) amino]-2 ''-methyl}-phenylaminocarbonylstaurosporine (1), together with staurosporine (2), was obtained from the culture broth of Actinomycetes Streptomyces sp. (172614). Their structures were elucidated by comprehensive spectroscopic analysis including UV, MS, NMR, and CD spectra. Pharmacological experiments revealed that 1 and 2 showed significant cytotoxicity against human colon tumor cell HCT-116.
- 出版日期2011
- 单位暨南大学; 中国科学院; 中国热带农业科学院; 国家新药筛选中心; 中国科学院上海药物研究所; 沈阳药科大学
