科研之友
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摘要
The synthesis and transformation of oripavidine (8) offer an efficient and simple route to highly active dopamine agonist apomorphines and a variety of important 14 beta-hydroxy-morphinan derivatives. Natural origin thebaine (6), the starting compound of the procedure, was converted into its N-{[1,2-bis(ethoxycarbonyl)hydrazinyl]methyl) counterpart. L-Selectride was found to be an efficient agent to perform a one-pot O- and N-deprotection at positions 3 and 17, respectively.
- 出版日期2009
