Association of alpha-ADD1 Gene and Hypertension Risk: A Meta-Analysis

作者：Liao Xiaoyang; Wang Weiwen; Zeng Zhi^*; Yang Zhiyi; Dai Hua; Lei Yi

来源：MEDICAL SCIENCE MONITOR, 2015, 21: 1634-1641.

DOI：10.12659/MSM.893191

• Genes, Dominant
• Hypertension
• Sterol Regulatory Element Binding Protein 1

Background: Results regarding the association between alpha-adducin (ADD1) gene and essential hypertension (EH) risk remain inconsistent. Therefore, we performed this meta-analysis to investigate this association.
Material/Methods: We comprehensively searched published literature from PubMed and Embase. All studies analyzing the association between ADD1 Gly460Trp polymorphism and EH risk were included. Fixed-or random-effects model was used to calculate pooled odds ratio (OR) with 95% confidence interval (CI).
Results: Data synthesis showed an increased risk of EH in T allele variant carriers with Asian descent, for GG vs. TT (OR=0.750, 95% CI: 0.585-0.960; P=0.022), recessive model (OR=1.196, 95% CI: 1.009-1.418; P=0.039), dominant model (OR=0.826, 95% CI: 0.693-0.985; P=0.033), and allelic model (OR=0.859, 95% CI: 0.756-0.964; P=0.01), respectively. However, no statistical differences were observed in Blacks and Caucasians.
Conclusions: The findings showed the association of the T allele in ADD1 gene with EH susceptibility in Asians. However, well-designed studies involving gene-gene and gene-environment interactions should be considered in future.

• 出版日期2015-6-4
• 单位四川大学