Applications of ring closing metathesis. Total synthesis of (+/-)-pseudotabersonine

作者：Cheng Bo; Sunderhaus James D; Martin Stephen F^*

来源：Tetrahedron, 2015, 71(39): 7323-7331.

DOI：10.1016/j.tet.2015.04.082

• Double ring-closing metathesis
• Multicomponent assembly process
• Alkaloid
• Total synthesis

A novel approach to the Aspidosperma family of alkaloids was developed and applied to a concise total synthesis of (+/-)-pseudotabersonine that was accomplished in 11 steps. Key transformations include a stepwise variant of a Mannich-like multicomponent assembly process, a double ring-closing metathesis sequence, and a one-pot deprotection/cyclization reaction.

• 出版日期2015-9-30