The tax gene sequences form two divergent monophyletic lineages corresponding to types I and II of simian and human T-Cell leukemia lymphotropic viruses

作者：Giri A; Slattery JP; Heneine W; Gessain A; Rivadeneira E; Desrosiers RC; Rosen L; Anthony R; Pamungkas J; Iskandriati D; Richards AL; Herve V; McClure H; OBrien SJ; Franchini G

来源：Virology, 1997, 231(1): 96-104.

DOI：10.1006/viro.1997.8511

Evolutionary associations of human and simian T-cell leukemia/lymphotropic viruses I and II (HTLV-I/II and STLV-I/II) are inferred from phylogenetic analysis of lax gene sequences. Samples studied consisted of a geographically diverse assemblage of viral strains obtained from 10 human subjects and 20 individuals representing 12 species of nonhuman primates. Sequence analyses identified distinct substitutions, which distinguished between viral types I and II, irrespective of host species. Phylogenetic reconstruction of nucleotide sequences strongly supported two major evolutionary groups corresponding to viral types I and II. With the type I lineage, clusters were composed of strains from multiple host species. A genetically diverse, monophyletic lineage consisting of eight new viral strains from several species of Asian macaques was identified. The second lineage consisted of a monophyletic assemblage of HTLV-II/STLV-II strains from Africa and the New World, including an isolate from a pygmy chimp (Pan paniscus) as an early divergence within the lineage. High levels of genetic variation among strains from Asian STLV-I macaque suggest the virus arose in Asia. Evidence of the origin of the type II virus is less clear, but diversity among HTLV-II variants from a single isolated population of Mbati villagers is suggestive but not proof of an African origin.

• 出版日期1997-4-28