A chromenoquinoline-based fluorescent off-on thiol probe for bioimaging

作者:Kand Dnyaneshwar; Kalle Arunasree Marasanapalli; Varma Sreejith Jayasree; Talukdar Pinaki*
来源:Chemical communications, 2012, 48(21): 2722-2724.
DOI:10.1039/c2cc16593g

摘要

A new chromenoquinoline-based fluorescent off-on thiol probe 2 is reported. In aqueous buffer solutions at physiological pH, the probe exhibited 223-fold enhancement in fluorescence intensity by a Michael addition of cysteine to the maleimide appended to a chromenoquinoline. Cell permeability and live cell imaging of thiols are also demonstrated.

  • 出版日期2012