First total synthesis of 6-epi-phomonol

作者：Garrido Fatima; Santalla Hugo; Gomez Generosa^*; Fall Yagamare^*

来源：Tetrahedron Letters, 2016, 57(24): 2631-2632.

DOI：10.1016/j.tetlet.2016.05.006

• Phomonol
• Natural product synthesis
• Tetrahydropyran
• Michael addition
• Cuprates

We describe a new and efficient total synthesis of 6-epi-phomonol from commercially available tri-O-acetyl-D-glucal. A key feature of the synthesis involves a stereoselective Michael addition using a magnesium cyanocuprate.

• 出版日期2016-6-15