Application of cryoablation to treat peritoneal carcinomatosis from gastric cancer in a rabbit model

作者：Yang, Yi; Ma, Wei-Wei; Zhou, Min-Wei; Chen, Zong-You; Xiang, Jian-Bin; Li, Zhen-Yang; Sung, Bo^*; Gu, Xiao-Dong^*

来源：Cryobiology, 2018, 85: 12-16.

DOI：10.1016/j.cryobiol.2018.10.263

• Cryoablation
• Peritoneal carcinomatosis
• Gastric cancer

Objectives: Peritoneal carcinomatosis is one of the causes of death in patients with advanced gastric cancer. We assumed that cryoablation could be applied as adjuvant therapy to control peritoneal carcinomatosis from gastric cancer.
Methods: We investigated the feasibility of cryoablation technique in rabbit model using a novel cryoablation balloon probe. The cryozones were harvested 7 days after cryoablation for histological evaluation. The levels of cytokines in the peripheral blood of rabbits were also detected.
Results: The results demonstrated that cryoablation could be applied in a rabbit model of peritoneal carcinomatosis from gastric cancer. Seven days after cryoablation, necrotic tumor cells could be seen the cryozones. Higher level of IFN-gamma was observed. The level of IL-10 was decreased after treatment.
Conclusions: The findings provided the experimental basis for the future application of cryoablation in patients.

• 出版日期2018-12
• 单位复旦大学