Antihyperglycemic, antihyperlipidemic and antioxidant activities of polysaccharides from Catathelasma ventricosum in streptozotocin-induced diabetic mice

作者：Liu, Yuntao; Sun, Jun; Rao, Shengqi; Su, Yujie; Yang, Yanjun^*

来源：Food and Chemical Toxicology, 2013, 57: 39-45.

DOI：10.1016/j.fct.2013.03.001

• Mushroom
• Polysaccharides
• Diabetes mellitus
• Streptozotocin

It is the first time to extract polysaccharides (CVPs) from Catathelasma ventricosum. The antihyperglycemic and antioxidant activity of CVPs in streptozotocin-induced diabetic mice were examined. Compared with untreated diabetic mice, the administration of CVPs for 30 days caused a significant decrease in the concentrations of blood glucose, total cholesterol (TC), triglycerides (TGs), low-density lipoprotein-cholesterol (LDL-C) and maleic dialdehyde (MDA), and a significant increase in the concentrations of high density lipoprotein-cholesterol (HDL-C) and the activities of antioxidant enzymes. Specially, when normal mice were treated with CVPs, all detection indexes and pathologic morphologies of liver, kidney and pancreas are similar to untreated normal mice, which indicated CVPs are safe for normal mice. In addition, the average molecular weight of CVPs was estimated to be from 3.7 x 10(3) to 1.7 x 10(7) Da and they were mainly composed of glucose (93.5%) with the conformation of ot-o-Glucopyranose.

• 出版日期2013-7
• 单位食品科学与技术国家重点实验室; 江苏大学; 扬州大学; 江南大学