Antibodies to Cyclic Citrullinated Peptides (Anti-CCP) as a Marker of Association between Type 1 Diabetes Mellitus (T1DM) and Rheumatoid Arthritis (RA) in Children and Adolescent

作者：Shahin Doaa; Swelam Rawia A; Fathy Abeer; Shahin Dina A; Attiya Mohamed

来源：Life Science Journal-Acta Zhengzhou University Overseas Edition, 2013, 10(1): 3061-3065.

Aims/Introduction: The association between Type 1 diabetes mellitus (T1DM) and rheumatoid arthritis (RA) remains controversial. The aim of this work was to find out the prevalence of anti-CCP in children and adolescences with T1DM and to determine whether anti-CCP could serve as marker for the development of RA in these patients. Material and Methods: We studied 42 children and adolescents with T1DM, 20 patients with RA, and 40 healthy age and sex matched controls. The studied groups were investigated for anti-CCP and RF and the result were statistically analyzed. Results: The number of anti-CCP positive patients in the diabetic group was not statistically different when compared with the healthy control group (1 vs. 0, P = 1) but was statistically lower than in the RA group (1 vs. 9, P%26lt;0.0001). Family history of RA was detected in only two of the diabetic patients with no significant difference than the control group. Family history of first degree relative with type 1 DM was not statistically significant different between the RA group and the control population (p=0.4). Conclusions: No significant difference in anti-CCP antibodies expression in patients with T1DM than the healthy control. Screening of anti-CCP antibodies may not appear to be useful in the follow-up of patients with type 1DM unless there are joint abnormalities.

• 出版日期2013