A novel and efficient procedure for the preparation of 4,4 '-bis(chloromethyl)biphenyl by chloromethylation of biphenyl catalyzed by PEG(1000)-DAIL under homogeneous catalysis in aqueous media

作者：Hu Yu Lin; Lu Ming^*; Ge Qiang; Wang Peng Cheng; Lu Ting Ting

来源：Journal of Industrial and Engineering Chemistry, 2010, 16(4): 615-619.

DOI：10.1016/j.jiec.2010.03.005

• 4,4 '-bis(Chloromethyl)biphenyl
• Chloromethylation
• PEG(1000)-DAIL
• Thermoregulated ionic liquid biphasic system

As described in this article, 4,4'-bis(chloromethyl)biphenyl was obtained in 85% excellent yield by chloromethylation of biphenyl catalyzed by the recyclable temperature-dependant phase-separation system that comprised the dicationic acidic ionic liquid PEG(1000)-DAIL and methylcyclohexane under homogeneous catalysis in aqueous media. Compared to other synthetic methods, the novel method not only enhanced the yield, but also made the operating units easy workup. The mechanism of chloromethylation reaction and the process of catalysis in the thermoregulated ionic liquid bi-phase system were proposed.

• 出版日期2010-7-25
• 单位南京理工大学