Diverse Pathogenicity of Equine Herpesvirus 1 (EHV-1) Isolates in CBA Mouse Model

作者：Yu Mi Htay Htay; Kasem Samy Gomaa Ahmed; Tsujimura Koji; Matsumura Tomio; Yanai Tokuma; Yamaguchi Tsuyoshi; Ohya Kenji; Fukushi Hideto^*

来源：Journal of Veterinary Medical Science, 2010, 72(3): 301-306.

DOI：10.1292/jvms.09-0337

• equine
• herpesvirus
• pathogenicity

The pathogenicity of equine herpesvirus 1 (EHV-1) isolates of Japan were evaluated by using the CBA mouse model CBA mice were inoculated with mitt Japanese EHV-1 strains (89c1. 90c16. 90c18. 97c11. 98c12, 00c19. Old l and HH-1) and one Bluish strain (Ab4p) 89cl caused slight body weight loss and nervous signs in mice at 8 days post in (dpi) Severe weight loss and nervous sums were observed in mice inoculated with Ab4p at 6 dpi The other strains did not cause appatent clinical stuns in viruses were recovered front the lungs of all groups at 2 dpi Histopathological analysis revealed interstitial pneumonia in the lungs of all mice inoculated with EHV-1 Encephalitis or meningoencephalitis was observed in the brains of mice inoculated with 89c1, 90c18. 97c11, 98c12. 01c1 and Ab4p Japanese EHV-1 strains showed low pathogenicity in CBA mice, whereas the sequential affects a infection are similar to those oldie highly pathogenic strain Ab4p These results suggest that Field isolates of EHV-1 have varying degrees of pathogenicity m CBA mice

• 出版日期2010-3