Ability of mini-implant-facilitated micro-osteoperforations to accelerate tooth movement in rats

作者：Cheung Tracy; Park Juyoung; Lee Deborah; Kim Catherine; Olson Jeffrey; Javadi Shadi; Lawson Gregory; McCabe James; Moon Won; Ting Kang; Hong Christine^*

来源：American Journal of Orthodontics and Dentofacial Orthopedics, 2016, 150(6): 958-967.

DOI：10.1016/j.ajodo.2016.04.030

Introduction: Although current techniques for accelerated tooth movement often involve invasive surgical procedures, micro-osteoperforations (MOPs) using mini-implants may facilitate orthodontic tooth movement without raising flaps, reduce surgical risks, and increase patient acceptance. In this study, we evaluated the effectiveness of mini-implant-facilitated MOPs in inducing accelerated tooth movement and investigated the potential risks for root resorption. Methods: Five MOPs were placed on the left side around the maxillary first molars in 6 rats using an automated mini-implant driver, whereas the right side received no MOPs as the control. Closed-coiled springs were secured from incisors to first molars for orthodontic tooth movement. Tooth movement was measured, and samples underwent radiologic and histologic analyses. Results: The MOP side exhibited a 1.86-fold increase in the rate of tooth movement with decreased bone density and bone volume around the first molars compared with the control side. Hematoxylin and eosin and tartrate-resistant acid phosphatase analyses showed increased numbers of osteoclasts as well as new bone formation. Three-dimensional volumetric analysis of all 5 roots of the maxillary first molars demonstrated no statistically significant difference in root volumes. Conclusions: Mini-implant-facilitated MOPs accelerated tooth movement without increased risk for root resorption and therefore may become a readily available and efficient treatment option to shorten orthodontic treatment time with improved patient acceptance.

• 出版日期2016-12