ACCELERATION OF BONE DEFECT HEALING AND REGENERATION BY LOW- INTENSITY ULTRASOUND RADIATION FORCE IN A RAT TIBIAL MODEL

作者：Liu, Jingbo; Li, Xiaofei; Zhang, Dongye; Jiao, Jian; Wu, Lin; Hao, Fengyu; Qin, Yi-Xian^*

来源：Ultrasound in Medicine and Biology, 2018, 44(12): 2646-2654.

DOI：10.1016/j.ultrasmedbio.2018.08.002

• Low-intensity pulsed ultrasound
• Acoustic radiation force
• Bone defect
• Trauma
• Bone regeneration
• Osteogenesis
• Fracture healing

The objective was to evaluate the effect of low-intensity pulsed ultrasound (LIPUS)-induced acoustic radiation force on trabecular bone defect repair and healing in a rat tibial model. A uniform surgical defect, 3.5 mm in diameter, was generated in the proximal bilateral tibial region of rats (N = 20). LIPUS was applied to the defects in the left tibia for 20 min every day for 2 wk. Contralateral defects in the right tibia served as a control without active LIPUS treatment. The micro-computed tomography data revealed that LIPUS-treated tibia exhibited higher bone volume/total volume, connectivity density, trabecular number, and bone mineral density and significantly lower trabecular separation. Histomorphometry analysis indicated a similar trend. Mechanical testing data revealed that LIPUS treatment significantly increased bone stiffness relative to that of the control group. Short-term (2-wk) LIPUS therapy initiated trabecular bone repair and regeneration in large trabecular bone defects. whereas cortical bone remained in the initial non-mineralization stage. (E-mail: Yi-Xian.Qin@StonyBrook.

• 出版日期2018-12
• 单位中国医科大学