科研之友
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摘要
Oxidative stress is involved in the pathogenesis of cardiovascular (CV) risk and endothelial dysfunction represents the predictor of atherosclerosis starting early in the life. The assessment of endothelial function is able to detect cardiovascular disease in asymptomatic patients. Polyphenol-rich nutrients are known to reduce oxidative stress and increasing nitric oxide generation. The effect of a cocoa derived polyphenols+myo-inositol on endothelial function has never been investigated. We studied in a series of volunteers (20 healthy subjects-CTR and 10 subjects affected by metabolic syndrome-MS) the acute vascular effects of a single assumption of a fix dose of polyphenols and myo-inositol by using Endopat2000. The administration induced a significant improvement of endothelial function in the MS population (+37% vs. baseline, p<0.01); also, when a subgroup of CTR according to the presence of endothelial dysLnRHI <0.51 - n=10 subject) or normal endothelial LnRHI >0.51 - n=10 subject)] was investigated we found a significant improvement in subjects affected by endothelial dysfunction only (+ 69%, p< 0.01). These preliminary results suggest that acute assumption of cocoa-derived polyphenols+myo-inositol is able to improve vascular reactivity in MS and also in young subjects affected by endothelial dysfunction.
- 出版日期2016-8
