Angiogenin/Ribonuclease 5 Is an EGFR Ligand and a Serum Biomarker for Erlotinib Sensitivity in Pancreatic Cancer

作者：Wang Ying Nai; Lee Heng Huan; Chou Chao Kai; Yang Wen Hao; Wei Yongkun; Chen Chun Te; Yao Jun; Hsu Jennifer L; Zhu Cihui; Ying Haoqiang; Ye Yuanqing; Wang Wei Jan; Lim Seung Oe; Xia Weiya; Ko How Wen; Liu Xiuping; Liu Chang Gong; Wu Xifeng; Wang Huamin; Li Donghui; Prakash Laura R; Katz Matthew H; Kang Yaan; Kim Michael; Fleming Jason B; Fogelman David; Javle Milind; Maitra Anirban; Hung Mien Chie

来源：Cancer Cell, 2018, 33(4): 752-+.

DOI：10.1016/j.ccell.2018.02.012

• EGFR inhibitor
• EGFR ligand
• PDAC
• angiogenin
• erlotinib
• receptor tyrosine kinase
• ribonuclease
• serum biomarker

Pancreatic ribonuclease (RNase) is a secreted enzyme critical for host defense. We discover an intrinsic RNase function, serving as a ligand for epidermal growth factor receptor (EGFR), a member of receptor tyrosine kinase (RTK), in pancreatic ductal adenocarcinoma (PDAC). The closely related bovine RNase A and human RNase 5 (angiogenin [ANG]) can trigger oncogenic transformation independently of their catalytic activities via direct association with EGFR. Notably, high plasma ANG level in PDAC patients is positively associated with response to EGFR inhibitor erlotinib treatment. These results identify a role of ANG as a serum biomarker that may be used to stratify patients for EGFR-targeted therapies, and offer insights into the ligand-receptor relationship between RNase and RTK families.

• 出版日期2018-4-9
• 单位University of Texas, MD Anderson Cancer Center; The University of Texas, MD Anderson Cancer Center; University of Texas Health Science Center; University of Texas M.D. Anderson Cancer Center; University of Texas M. D. Anderson Cancer Center; University of Texas, M.D. Anderson Cancer Center; The university of Texas,M.D.Anderson Cancer Center; The University of Texas MD, Anderson Cancer Center; UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER; University of Texas MD Anderson Cancer Center; the university of Texas MD Anderson Cancer Center; University of Texas M.D.Anderson Cancer Center; The University of Texas M.D anderson Cancer Center; The University of Texas Health Science Center; The University of Texas M.D.Anderson Cancer Center; The University of Texas MD Anderson Cancer Center; University of Texas,M.D.Anderson Cancer Center; University Of Texas MD Anderson Cancer Center; The University of Texas M.D Anderson Cancer Center; University of Texas M.D.Anderson cancer center; The university of Texas Health Science Center