Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

作者：Michaud Mickael; Martins Isabelle; Sukkurwala Abdul Qader; Adjemian Sandy; Ma Yuting; Pellegatti Patrizia; Shen Shensi; Kepp Oliver; Scoazec Marie; Mignot Gregoire; Rello Varona Santiago; Tailler Maximilien; Menger Laurie; Vacchelli Erika; Galluzzi Lorenzo; Ghiringhelli Francois; di Virgilio Francesco; Zitvogel Laurence^*; Kroemer Guido

来源：Science, 2011, 334(6062): 1573-1577.

DOI：10.1126/science.1208347

Antineoplastic chemotherapies are particularly efficient when they elicit immunogenic cell death, thus provoking an anticancer immune response. Here we demonstrate that autophagy, which is often disabled in cancer, is dispensable for chemotherapy-induced cell death but required for its immunogenicity. In response to chemotherapy, autophagy-competent, but not autophagy-deficient, cancers attracted dendritic cells and T lymphocytes into the tumor bed. Suppression of autophagy inhibited the release of adenosine triphosphate (ATP) from dying tumor cells. Conversely, inhibition of extracellular ATP-degrading enzymes increased pericellular ATP in autophagy-deficient tumors, reestablished the recruitment of immune cells, and restored chemotherapeutic responses but only in immunocompetent hosts. Thus, autophagy is essential for the immunogenic release of ATP from dying cells, and increased extracellular ATP concentrations improve the efficacy of antineoplastic chemotherapies when autophagy is disabled.

• 出版日期2011-12-16