Neolignan and megastigmane glucosides from the aerial parts of Isodon japonicus with cell protective effects on BaP-induced cytotoxicity

作者：Matsumoto Takahiro; Nakamura Seikou; Nakashima Souichi; Ohta Tomoe; Ogawa Keiko; Fukaya Masashi; Tsukioka Junko; Hasei Tomohiro; Watanabe Tetsushi; Matsuda Hisashi^*

来源：Phytochemistry, 2017, 137: 101-108.

DOI：10.1016/j.phytochem.2017.02.007

• Isodon japonicas
• Lamiaceae
• Isodonoside
• Isodonmegastigmane
• Glucoside
• Neolignan
• Megastigmane

Six neolignan glucosides, named isodonosides I-VI, and a megastigmane glucoside named isodonmegastigmane I, were isolated together with 15 known compounds from the methanolic extract of aerial parts of Isodon japonicus cultivated in Tokushima, Japan. The chemical structures of the compounds were elucidated based on their MS and NMR spectroscopic analysis. The absolute configurations of the neolignan and megastigmane glucosides were determined by derivatizations, by ECD (electronic circular dicroism) Cotton effect approximation, and by the modified Mosher's method. In addition, a significant cell protective effects of neolignan glucosides on benzolajpyrene-induced cytotoxicity was found.

• 出版日期2017-5