Assembly of bioactive multilayered nanocoatings on pancreatic islet cells: incorporation of alpha 1-antitrypsin into the coatings

作者:Zhi Zheng Liang*; Singh Jashandeep; Austin Amazon L F; Hope David C D; King Aileen J; Persaud Shanta J; Jones Peter M
来源:Chemical communications, 2015, 51(53): 10652-10655.
DOI:10.1039/c5cc02570b

摘要

A spontaneous multilayer deposition approach for presenting therapeutic proteins onto pancreatic islet surfaces, using a heparin polyaldehyde and glycol chitosan alternating layering scheme, has been developed to enable the nanoscale engineering of a microenvironment for transplanted cells. The nanocoating incorporating alpha 1-antitrypsin, an antiinflammatory protein, exhibited effective anti-coagulant activities in vitro.

  • 出版日期2015