Using neutron protein crystallography to understand enzyme mechanisms

作者：Glusker Jenny P^*; Carrell H L; Kovalevsky Andrey Y; Hanson Leif; Fisher S Zoe; Mustyakimov Marat; Mason Sax; Forsyth Trevor; Langan Paul

来源：Acta Crystallographica Section D-Biological Crystallography, 2010, 66: 1257-1261.

DOI：10.1107/S0907444910027915

• neutron diffraction
• enzyme mechanisms
• d-xylose isomerase

A description is given of the results of neutron diffraction studies of the structures of four different metal-ion complexes of deuterated d-xylose isomerase. These represent four stages in the progression of the biochemical catalytic action of this enzyme. Analyses of the structural changes observed between the various three-dimensional structures lead to some insight into the mechanism of action of this enzyme.

• 出版日期2010-11