A novel catalytic asymmetric route towards skipped dienes with a methyl-substituted central stereogenic carbon

作者：Huang Yange; Fananas Mastral Martin; Minnaard Adriaan J; Feringa Ben L^*

来源：Chemical communications, 2013, 49(32): 3309-3311.

DOI：10.1039/c3cc41021h

A highly efficient method for the enantioselective synthesis of 1,4-dienes (skipped dienes) with a methyl-substituted central stereogenic carbon using copper-catalysed asymmetric allylic alkylation of diene bromides was developed. Excellent regio- and enantioselectivity (up to 97:3 S(N)2%26apos;/S(N)2 ratio and 99% ee) were achieved with broad substrate scope.

• 出版日期2013