An efficient synthesis of [D-6]leucocrystal violet

作者：Yang Weicheng; Luo Yong^*; Liu Weixia; Deng Xiaojun; Du Xiaoning; Li Meihua

来源：Journal of Labelled Compounds and Radiopharmaceuticals, 2011, 54(4): 211-213.

DOI：10.1002/jlcr.1849

• [D-6]leucocrystal violet
• synthesis
• labelled internal standards

This report presents an efficient synthesis of [D-6]leucocrystal violet. Esterification of p-toluenesulphonyl chloride with [D-4]methanol provided [D-3]methyl p-toluenesulphonate, which was used to methylate aniline to give [D-6]N,N-dimethylaniline. Condensation of [D-6]N,N-dimethylaniline with bis[4-(dimethylamino) phenyl] methanol afforded [D-6]leucocrystal violet in an overall yield of 30% in three steps.

• 出版日期2011-4