Anti-inflammatory neolignans from the roots of Magnolia officinalis

作者：Shih Hung Cheng; Kuo Ping Chung; Wuc Shwu Jen; Hwang Tsong Long; Hung Hsin Yi; Shen De Yang; Shieh Po Chuen; Liao Yu Ren; Lee E Jian; Gu Qiong; Lee Kuo Hsiung^*; Wu Tian Shung^*

来源：Bioorganic & Medicinal Chemistry, 2016, 24(7): 1439-1445.

DOI：10.1016/j.bmc.2016.01.049

• Neolignans
• Anti-inflammatory activity
• Magnolia officinalis
• Houpulins E-M

Nine neolignan derivatives (1-9) were characterized from the roots of Magnolia officinalis, and their structures were elucidated based on spectroscopic and physicochemical analyses. Among them, houpulins E (1) and M (9) possess novel homo- and trinor-neolignan skeletons. In addition, 15 known compounds (10-24) were identified by comparison of their spectroscopic and physical data with those reported in the literature. Some of the purified constituents were examined for anti-inflammatory activity and, among the tested compounds, houpulins G (3), I (5), J (6), and 2,20-dihydroxy-3-methoxy-5,5'-di-(2-propenylbiphenyl) (19) significantly inhibited superoxide anion generation and elastase release with IC50 values ranging from 3.54 to 5.48 mu M and 2.16 to 3.39 mu M, respectively. Therefore, these neolignan derivatives have tremendous potential to be explored as anti-inflammatory agents.

• 出版日期2016-4-1
• 单位中国医科大学; 长春大学