科研之友
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摘要
BackgroundToll-like receptor 4 (TLR4) plays an important role in innate immunity. Activation of innate immune response and subsequent chronic low-grade inflammation are thought to be involved in the pathogenesis of type 2 diabetes. In this study, we aimed to investigate the association of TLR4 variants with type 2 diabetes in the Chinese population. @@@ MethodsSeven tag single nucleotide polymorphisms (SNPs) of TLR4 based on HapMap Chinese data were genotyped in the Shanghai Chinese, including 3404 type 2 diabetes patients and 3401 controls. The controls were extensively phenotyped for the traits related to glucose metabolism and insulin secretion. @@@ ResultsIn total participants, we identified that rs10759932 and rs1927911 were associated with type 2 diabetes (odds ratio 1.106, P=0.009 for rs10759532, odds ratio 1.092, P=0.013 for rs1927911). rs11536889 showed a trend association with type 2 diabetes (odds ratio 0.957, P=0.057). This SNP was also associated with 2-h plasma glucose (P=0.033) and high-density lipoprotein-cholesterol (P=0.031). In female participants, rs10759932, rs1927911 and rs11536889 were associated with type 2 diabetes (odds ratio 1.176, P=0.002 for rs10759932, odds ratio 1.136, P=0.009 for rs1927911, odds ratio 0.882, P=0.024 for rs11536889). Besides, rs11536889 was significantly associated with 2-h plasma glucose (P=0.050) and HOMA-B (P=0.046) with adjusting for age and body mass index in female normal subjects. @@@ ConclusionsWe conclude that genetic variants of TLR4 are associated with type 2 diabetes in the Chinese population, especially in female subjects.
- 出版日期2015-7
- 单位上海交通大学; 上海市临床检验中心
