A facile one-pot sonochemical synthesis of surface-coated mannosyl protein microspheres for detection and killing of bacteria

作者：Skirtenko Natalia; Richman Michal; Nitzan Yeshayahu; Gedanken Aharon; Rahimipour Shai^*

来源：Chemical Communications, 2011, 47(45): 12277-12279.

DOI：10.1039/c1cc13518j

We report a remarkably facile one-pot sonochemical approach to prepare protein microspheres whose shells are covalently decorated with a mannosyl derivative to target Escherichia coli (E. coli), while their cores are encapsulated with tetracycline. Conjugated microspheres induced the agglutination of E. coli and increased the anti-bacterial activity of the encapsulated tetracycline by five fold.

• 出版日期2011