A short history of heme dioxygenases: rise, fall and rise again

作者:Raven Emma L
来源:Journal of Biological Inorganic Chemistry, 2017, 22(2-3): 175-183.
DOI:10.1007/s00775-016-1412-5

摘要

It is well established that there are two different classes of enzymes-tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO)-that catalyse the O-2-dependent oxidation of l-tryptophan to N-formylkynurenine. But it was not always so. This perspective presents a short history of the early TDO and IDO literature, the people that were involved in creating it, and the legacy that this left for the future.

  • 出版日期2017-4