Autophagy of HSP70 and chelation of lysosomal iron in a non-redox-active form

作者：Kurz Tino; Brunk Ulf T^*

来源：Autophagy, 2009, 5(1): 93-95.

DOI：10.4161/auto.5.1.7248

• apoptosis
• autophagy
• HSP70
• iron
• lysosomes
• reactive oxygen species (ROS)

Lysosomes contain most of the cell's supply of labile iron, which makes them sensitive to oxidative stress. To keep lysosomal labile iron at a minimum, a cellular strategy might be to autophagocytose iron-binding proteins that temporarily would chelate iron in a nonredox-active form. Previously we have shown that autophagy of metallothioneins, as well as of non-Fe-saturated ferritin, meets this goal. Here we add another stress-regulated protein to the list, namely HSP70.

• 出版日期2009-1