Evaluation of risk factors for body weight increment in psoriatic patients on infliximab: a multicentre, cross-sectional study

作者：Mahe E^*; Reguiai Z; Barthelemy H; Quiles Tsimaratos N; Chaby G; Girard C; Esteve E; Maccari F; Descamps V; Schmutz J L; Begon E; Bravard P; Maillard H; Boye T; Beauchet A; Sigal M L

来源：Journal of the European Academy of Dermatology and Venereology, 2014, 28(2): 151-159.

DOI：10.1111/jdv.12066

Background A significant weight gain has been reported in patients with psoriasis treated with anti-tumour necrosis factor-alpha agents. Among these patients, there are contradictory results about risk factors for weight gain. Objective Assessing risk factors for weight increment in psoriatic patients on infliximab (IFX). Methods This study was a 4-month, non-interventional, cross-sectional, multicentre study on adults with psoriasis performed in 19 French dermatological centres. All the patients who received IFX for at least 1year were prospectively included, with retrospective analysis of data. Impact of sex, age, severity of the disease, cardiovascular and metabolic comorbidities, and previous and simultaneous systemic treatments on weight changes, was analysed. Weight gain was defined as an increment of more than 2% of baseline weight. Results Overall, 191 psoriatic patients (males: 68.6%; mean age: 46.9years) were included. Mean weight gain was 1.6kg (2.1%) after 1year of IFX. Half (48.2%) suffered from a weight gain, and 9.9% from a weight increment of 10% or more. Baseline weight and Body Mass Index, and cardiovascular and metabolic comorbidities did not influence weight. Men (P=0.007) and patients with severe psoriasis (BSA, P=0.005) had a tendency to put on weight. Patients with a hospital dietary follow-up (P=0.01; OR=0.36 [0.16-0.79]) and patients on methotrexate (P=0.03; OR=0.41 [0.18-0.93]) during IFX treatment are thinner, in a multivariate analysis. Conclusion Severe weight increment is frequent on IFX treatment, mainly in men, and patients with severe psoriasis. Dietary follow-up or simultaneous use of methotrexate could limit this weight increment.

• 出版日期2014-2